Lischinsky Lab at the National Institute of
Environmental Health Sciences (NIEHS)
-Not an official NIH website-
Research
Striving to pursue novel and exciting research questions by integrating developmental and circuit neuroscience approaches for the study of social behaviors
How are social behaviors established during postnatal development?
Project 1
Social behaviors, including aggression and mating can take place without prior experience. Therefore, there must be developmental events setting up the brain circuits for the correct processing of social information and execution of behavioral actions. We aim to take a multi-level approach to understand the cell subpopulations involved, the circuits necessary and the impact of hormones for the processing of social sensory information and social behaviors during postnatal development.
Early-life stressors, including adversity (ELA), social isolation and environmental toxins are all environmental factors that can play a role in shaping our behaviors during puberty and adulthood and can lead to long-lasting neurological and behavioral consequences. We aim to elucidate how neuronal circuits are disrupted by environmental stressors during infancy, which will allow us to develop interventions and treatments to prevent associated mental illnesses later in life.
How are environmental factors
disrupting the social behavior network?
Project 2
Our goal is to undertake a brain-wide approach to uncover distinct transcriptionally-defined subpopulations that are functionally relevant for the production of social behaviors and social sensory processing. Multiple regions in the social behavior network and beyond have shown sex-specific differences. Therefore, we will pursue this question by studying both males and females and determining similarities and divergences across sexes.
How are distinct transcriptionally-defined subpopulations orchestrating social behaviors across sexes?
Project 3
Tools for dissecting the circuits for social behaviors
In vivo neuronal activity and neurotransmitter
recordings at the population and single-cell level via miniscope imaging and single and multi-fiber photometry in freely-moving mice
Viral tracing tools to uncover anatomical and functional circuit connectivity
Cellular and circuit manipulations through chemogetic and optogenetic strategies
during social behaviors
Measuring rodent behavior through social behavioral assays and during environmental manipulations. Tracking mouse behavior in
biased and unbiased fashions
Molecular approaches including immunohistomechistry, RNAscope and sequencing for determining cell identity